Multisensory design is a promising approach that fosters exceptional workplaces by bridging user experience demands and prioritizing both functional needs and diverse human factors. Our research explores the role of multisensory, personality-based, and strengths-based factors in creating inclusive and effective work environments that prioritize wellbeing and productivity - employing social science, behavioral psychology, and environmental design to develop evidence-based recommendations that enable more effective activity-based-working. It is generally known that organizations can accommodate diverse needs by providing a range of space types for workers to choose from based on preference and activity (also known as activity-based-working). However, simply providing an even variety of spaces is not an efficient use of space. Leveraging extensive survey data, we've developed worker profiles and uncovered new insights for environmental planning. In addition to environmental attributes (e.g. level of noise, brightness, formality, enclosure), qualities studied include Big 5 personality traits (extroversion, conscientiousness, neuroticism, openness, and agreeableness), individual workflow preferences (e.g. synchronous vs asynchronous communication, auditory vs visual learning), and the 34 Clifton Strengths. We hypothesize that considering the relationships between these factors and incorporating them in the design process will lead to more successful and inclusive workplaces that achieve the level of customizability workers seek while maximizing the ability for employees to thrive. Many of these design information layers are new and nascent in terms of being tested in workplaces; however, findings indicate they offer insight around how to positively influence space utilization and elevate well-being, satisfaction, and productivity. By sharing our results and methodologies, we hope to contribute to the ongoing global reassessment of offices and repurposing of existing structures, while reinforcing the need to address the relationships between human factors and environmental preferences in office redesigns.